Financial Support

Once your benefits have been verified, if you need financial assistance, you may qualify for one of the programs offered by United Therapeutics. Notify your Specialty Pharmacy (SP) when scheduling shipment or contact ASSIST directly.

UT Co-pay Assistance Program

Orenitram Co-Pay Assistance Card

If you have a commercial or private insurance plan, we offer a co-pay assistance card to help cover some of your out-of-pocket expenses.

Most eligible patients pay as little as a $0.00 co-pay per month for Orenitram. The pharmacy will be reimbursed up to a maximum of $5,000 on the Orenitram prescription filled or maximum of $5,000 per 30-day period in the case of multiple prescriptions filled in the same 30-day period for a given patient. The patient will be responsible for any remaining balance in excess of the maximum program benefit.*

Terms and Conditions

*Patients must meet certain eligibility criteria to qualify for assistance. Patients receiving reimbursement under Medicare, Medicaid, VA, DoD (TRICARE), Indian Health Services, or similar federal or state programs, may not be eligible for some assistance. Some portion of this patient assistance may be administered by third-party patient assistance organizations. The Program is subject to additional state law restrictions. Patients residing in select states may not be eligible for the Program.

contact assist

Patient Assistance Program (PAP)

United Therapeutics offers a free medication program for uninsured and underinsured patients who meet eligibility requirements.

Call ASSIST at 1-877-864-8437 to find out if you qualify for financial support.

Other financial support resources

There are independent Patient Assistance Programs* available that offer financial assistance to PAH patients in need. Known patient assistance programs that support PAH are listed below, in no particular order.

*Independent patient assistance programs are fully separate from United Therapeutics, and United Therapeutics has no influence or control over these organizations. United Therapeutics has no control or insight into whether an independent PAP may or will approve an individual for assistance, and United Therapeutics does not receive any information about the status or decisiotn of a grant application.


If you have any questions about completing the referral form, contact ASSIST at 1-877-UNITHER (1-877-864-8437), Monday - Friday, 8:30am to 7:00pm ET.

Important Safety Information for Orenitram

Who should not take Orenitram?

Do not take Orenitram if you have severe liver problems.

What should I tell my healthcare provider before taking Orenitram?

Tell your healthcare provider:

  • If you have liver problems or diverticulosis.
  • If you are pregnant, breastfeeding, and/or plan to become pregnant or breastfeed. It is not known if Orenitram will harm your unborn baby or if Orenitram passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment with Orenitram.
  • About all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Orenitram and other medicines may affect each other causing side effects. Do not start any new medicine until you check with your healthcare provider. Especially tell your healthcare provider if you take another medicine that contains treprostinil, such as Remodulin® or Tyvaso®.

How should I take Orenitram?

  • Do not change your dose or suddenly stop taking Orenitram without first talking to your healthcare provider.
  • Orenitram is usually taken 3 times a day (about every 8 hours) or 2 times a day (about every 12 hours). Your healthcare provider will tell you how often you should take Orenitram. If you have side effects, your healthcare provider may tell you to change your dose or when you take Orenitram. Take Orenitram with food.
  • Swallow Orenitram tablets whole. Do not split, chew, crush, or break your Orenitram tablets. Do not take Orenitram tablets that are damaged or broken. If Orenitram tablets are not taken whole, they may release too much medicine at one time. This can lead to side effects.
  • If you miss your dose of Orenitram, take the missed dose as soon as possible with food.
  • If you miss 2 or more doses of Orenitram, call your healthcare provider to see if you need to change your dose.
  • If you take too much Orenitram, call your healthcare provider or go to the nearest hospital emergency room right away.
  • You may see the tablet shell in your stools (bowel movements). This is usually normal. The tablet shell is not digested. If you have diverticulosis, the tablet shell may get stuck in a blind pouch or diverticulum in your intestine.

What are the possible side effects of Orenitram?

Orenitram can cause serious side effects, including worsening of PAH symptoms.

  • Stopping Orenitram suddenly may cause worsening of your PAH symptoms. Do not change your dose or suddenly stop taking Orenitram without first talking to your healthcare provider.
  • The most common side effects of Orenitram include headache, diarrhea, nausea, vomiting, flushing, and pain in arms, legs, and jaw. These are not all of the possible side effects of Orenitram. Tell your healthcare provider if you have any side effect that bothers you or does not go away.
  • Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at or call 1-800-FDA-1088.

What is Orenitram?

Orenitram is a prescription medicine used to treat pulmonary arterial hypertension (PAH) which is high blood pressure in the arteries of your lungs. Orenitram can help slow down the progression of your disease and improve your ability to exercise. It is not known if Orenitram is safe and effective in children.

The risk information provided here is not comprehensive. To learn more about Orenitram, talk with your healthcare provider. Please see Full Prescribing Information and Patient Information at or call Customer Service at 1-877-UNITHER (1-877-864-8437).