ASSIST for ORENITRAM (treprostinil)

Financial Support

Orenitram Co-Pay Assistance Card

For patients with commercial or private insurance plans, we offer a co-pay card to help patients cover some of their out-of-pocket expenses.

Eligible patients may pay as little as a $5 of their co-pay expense for their first Orenitram prescription. After the first prescription each month, each subsequent prescription within a 30-day period will have a $0 co-pay. The pharmacy will be reimbursed up to a maximum of $5,000 on the Orenitram prescription filled or maximum of $5,000 per 30-day period in the case of multiple prescriptions filled in the same 30-day period for a given patient. The patient will be responsible for any remaining balance that is not covered by their initial $5 co-pay and the maximum program benefit.*

Terms and Conditions

*Patients must meet certain eligibility criteria to qualify for assistance. Patients receiving reimbursement under Medicare, Medicaid, VA, DoD (TRICARE), Indian Health Services, or similar federal or state programs, may not be eligible for some assistance. Some portion of this patient assistance may be administered by third-party patient assistance organizations. The Program is subject to additional state law restrictions. Patients residing in select states may not be eligible for the Program.

Patient Assistance Program (PAP) for uninsured or underinsured patients

If your patient does not have insurance, their insurance does not cover the medication, or they are underinsured, United Therapeutics offers medication free of charge to eligible patients. Please contact ASSIST to check your patient’s eligibility.

Questions?

You can call ASSIST at 1-877-864-8437, Monday - Friday, 8:30 am to 7:00 pm ET or email ASSIST at assist@unither.com.

Important reminder

Please remind your patients to keep the Specialty Pharmacy informed about their current insurance status.

Indication

Orenitram is a prostacyclin mimetic indicated for treatment of pulmonary arterial hypertension (PAH) (WHO Group 1) to delay disease progression and to improve exercise capacity.

The studies that established effectiveness included predominately patients with WHO functional class II-III symptoms and etiologies of idiopathic or heritable PAH (66%) or PAH associated with connective tissue disease (26%).

IMPORTANT SAFETY INFORMATION FOR ORENITRAM

CONTRAINDICATIONS

Avoid use of Orenitram in patients with severe hepatic impairment (Child Pugh Class C) due to increases in systemic exposure.

WARNINGS AND PRECAUTIONS

Abrupt discontinuation or sudden large reductions in dosage of Orenitram may result in worsening of PAH symptoms.

OThe Orenitram tablet shell does not dissolve. In patients with diverticulosis, Orenitram tablets can lodge in a diverticulum.

ADVERSE REACTIONS

In the 12-week, placebo-controlled, monotherapy study, and an event-driven, placebo-controlled, combination therapy study, adverse reactions that occurred at rates at least 5% higher on Orenitram than on placebo included headache, diarrhea, nausea, vomiting, flushing, pain in jaw, pain in extremity, hypokalemia, abdominal discomfort, and upper abdominal pain.

DRUG INTERACTIONS

Co-administration of Orenitram and the CYP2C8 enzyme inhibitor gemfibrozil increases exposure to treprostinil; therefore, Orenitram dosage reduction may be necessary in these patients.

SPECIFIC POPULATIONS

Animal reproductive studies with Orenitram have shown an adverse effect on the fetus. There are no adequate and well-controlled studies with Orenitram in pregnant women.

It is not known whether treprostinil is excreted in human milk or if it affects the breastfed infant or milk production.

Safety and effectiveness of Orenitram in pediatric patients have not been established.

Use of Orenitram in patients aged 65 years and over demonstrated slightly higher absolute and relative adverse event rates compared to younger patients. Caution should be used when selecting a dose for geriatric patients.

There is a marked increase in the systemic exposure to treprostinil in hepatically impaired patients.

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For additional information please see Full Prescribing Information or call Customer Service at 1-877-UNITHER (1-877-864-8437)